Integrative network modeling approaches to personalized cancer medicine
نویسندگان
چکیده
منابع مشابه
Integrative network modeling approaches to personalized cancer medicine.
The ability to collect millions of molecular measurements from patients is a now a reality for clinical medicine. This reality has created the challenge of how to integrate these vast amounts of data into models that accurately predict complex pathophysiology and can translate this complexity into clinically actionable outputs. Integrative informatics and data-driven approaches provide a framew...
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Despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. Chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...
متن کاملHuman Cancer Modeling: Recapitulating Tumor Heterogeneity Towards Personalized Medicine
Despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. Chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...
متن کاملhuman cancer modeling: recapitulating tumor heterogeneity towards personalized medicine
despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...
متن کاملLimits to Personalized Cancer Medicine.
Rapid advances in the molecular characterization of tumors, including complete gene sequencing of multiple cancers in the Cancer Genome Project, have led to an increased understanding of the molecular pathways that underlie cancer. These genomic changes differentiate tumors from normal tissues, permitting targeted treatments for several types of tumor and thereby extending survival and improvin...
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ژورنال
عنوان ژورنال: Personalized Medicine
سال: 2015
ISSN: 1741-0541,1744-828X
DOI: 10.2217/pme.14.87